In order to discuss the technical measures of the multi-directional water breakthrough, it is essential to find out the water breakthrough discipline and the understand the mechanism of the multi-round profile control technique. Therefore, we designed and the established the fracture-matrix visualization model with one-injection well for three production wells. The permeability between the different injection-production ends was inequality. By this model, we studied the migration characteristics and the plugging mechanism of the gel, the fluid diverting of subsequent water flooding and the distribution characteristics of the residual oil on the condition of the fracture-matrix. Through the core flow experiment of the shunt-wound sand-filled pipes with different permeability. And by the simulation of the interlayer heterogeneity, we compared the experimental data of the single and multi-round profile control measures. The results show that the multi-round profile control can fully play the synergistic effect to improve the performance and plug the fractured seepage channel effectively along with the promotion of the fluid diverting, and the profile control effect reduces with time of the injection. The multi-round profile control technique is better than the single profile control technique in the respect of adapting the fractured geological structure, and has a better effect on relieving the interlayer contradiction.