Water flooding is one of the most economical and effective measures for the sustainable and stable production of oil field and EOR(enhance oil recovery). However, formation scaling is inevitable in the process of long-term water flooding, which seriously affects and restricts the effect of oil field development. Taking injection-production unit as the research object, based on thermodynamic theory and solubility product rule, and considering the influence of formation temperature, pressure, scaling ion concentration and flow rate, the numerical models of formation scaling in injection-production unit was established, including pressure field model, temperature field model, porosity and permeability distribution model and formation scaling model. Meanwhile, according to the actual production data of oil field, mathematical simulation software—MATLAB—was used to carry out the case to analyze the influence of each factor on the total scaling amount, scaling range, distribution of scaling quantity and formation scaling on apparent water absorption index and permeability in injection-production unit. The results showed that the temperature of the immediate vicinity of the injection wells was low, the dissolution equilibrium constant was small and the flow rate was high, so that scaling was difficult. When in radial outward direction, the formation temperature increased, and the flow rate decreased greatly, which made it the most easy condition for scaling. Continue outward, when the scaling ion concentration was lower than the minimum scaling concentration, scale would no longer form.