Recently, positive progress has been made in the exploration and development for shale gas of the Wufeng-Longmaxi formation in the area with complex structure of the southeast area of Chongqing. In order to further deepen the understanding of shale gas accumulation in this area, based on the previous research results, by using the data such as experimental analysis, geophysical exploration, drilling, fracturing and gas testing, and starting from the key factors of controlling shale gas enrichment and high yield, typical target anatomy and mechanism analyses are carried out to summarize the rules of shale gas enrichment and high yield. Meanwhile, it is found that the enrichment and high yield of shale gas are controlled by three factors: sedimentary facies, preservation conditions and in-situ stress field, concretely speaking, deep-water shelf facies controls the scale of resources; preservation conditions control the degree of shale gas enrichment; in-situ stress field influences the effect of fracturing transformation and controls the yield of single well. To optimize shale gas sweet spot targets and well location deployment in complex structural areas, firstly, the resource basis for controlling shale gas enrichment should be evaluated, that is, the development degree and indicators of high-quality shale in deep-water shelf facies. Secondly, the intensity of tectonic movements is evaluated to determine the preservation conditions and enrichment degree of shale gas. Finally, it is preferred to deploy a shale gas well with a medium-curvature zone of moderate in-situ stress to facilitate high and stable yield. The research results have important guidance and reference significance for the exploration and development of shale gas in complex structural areas.